Developing the next generation of algorithms to understand the impact of the genotype on the phenotype

Individual genetic alterations can have direct impact on the phenotypes of the respective organisms. Such mutations can be useful for functional annotation of the respective regions of the genome and can be found between wildtype and mutant genomes, between distinct individuals of the same species, and between the genomic sequences of diverse species. The group develops new approaches to identify and to distinguish such differences from all other changes that do not affect the phenotypes.